This is a known and frustrating issue with Devil May Cry 4: Special Edition on PC, especially on modern GPUs (NVIDIA RTX 30/40 series, AMD RX 6000/7000 series) and Windows 10/11. The DXGI_ERROR_DEVICE_REMOVED error generally means the GPU crashed, was reset by the driver, or timed out — and the game lost connection to it.
Here’s an interesting, focused guide to tackle it, going beyond the usual “update drivers” advice. devil may cry 4 special edition dxgi error device removed
Download dxvk-2.x.tar.gz → extract d3d10.dll, d3d10_1.dll, dxgi.dll → place in game folder where DMC4SE.exe is. This bypasses native DX10 driver entirely. This is a known and frustrating issue with
(Only recommended if you’re comfortable with modding; works wonders on AMD GPUs.) Use DXVK (Translate DX10 to Vulkan) Download dxvk-2