Title:
JUQ‑565: A Novel Small‑Molecule Modulator of the PI3K‑Akt Pathway with Therapeutic Potential in Triple‑Negative Breast Cancer
Authors:
A. Patel¹, L. Nguyen², M. García‑López³, R. O. Kim⁴, S. K. Mehta⁵
Affiliations:
¹Department of Chemical Biology, University of Cambridge, United Kingdom
²Institute for Molecular Medicine, Seoul National University, South Korea
³Centro de Investigación Biomédica, Universidad de Buenos Aires, Argentina
⁴Department of Oncology, Stanford University School of Medicine, USA
⁵Division of Pharmacology, Indian Institute of Science, Bengaluru, India JUQ-565
Correspondence:
A. Patel (a.patel@cam.ac.uk)
| Parameter | Mouse | Rat | Human (in‑vitro) | |-----------|-------|-----|------------------| | Kinetic solubility (µM) | 38 | 33 | 41 | | Microsomal t₁⁄₂ (min) | 45 | 38 | 52 | | Plasma protein binding (fu) | 0.12 | 0.10 | 0.15 | | Oral F (mouse) | 62 % | 55 % | — | | Cmax (µM) after PO 30 mg kg⁻¹ | 6.8 | — | — | | AUC₀‑∞ (µM·h) | Title: JUQ‑565: A Novel Small‑Molecule Modulator of the
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Once I have a better understanding of your requirements, I'll do my best to assist you in crafting a well-written text! indicating a therapeutic window >
Essay Title:
JUQ‑565: A Next‑Generation Quantum‑Secure Communication Protocol
JUQ‑565 inhibited proliferation of all 8 TNBC lines with GI₅₀ values ranging from 4 nM (MDA‑MB‑231) to 12 nM (HCC‑70). Non‑transformed mammary epithelial cells (MCF‑10A) displayed a markedly higher GI₅₀ (≈ 2 µM), indicating a therapeutic window > 100‑fold. Western blot analysis revealed dose‑dependent suppression of p‑Akt (Ser473) and downstream p‑S6 after 2 h exposure, with complete de‑phosphorylation at ≤ 50 nM (Figure 2).